Methacrylated Hyaluronic Acid Powder

• Photocrosslinkable polymer: Enables light-triggered hydrogel formation with a compatible photoinitiator.

• Adjustable properties: Crosslinking behavior and gel stiffness can be tuned through formulation and substitution level.

• Multiple molecular weights: Options may range from tens of kDa to several hundred kDa.

• Variable substitution levels: Available degrees of methacrylation depend on the supplier and grade.

• Research applications: Suitable for evaluating hydrogel systems, biomaterial scaffolds, and bioinks.

• Quality documentation: COA, SDS, and analytical data may be requested, subject to availability.

Property	Specification
Product Name	Methacrylated Hyaluronic Acid
Abbreviations	HAMA, MeHA, HA-MA, MA-HA
Chemical Composition	Methacrylate-functionalized hyaluronic acid
CAS Number	Verify with supplier; some listings use 9067-32-7, but this may refer to the parent hyaluronic acid or sodium hyaluronate
Appearance	White to off-white powder, lyophilized solid, or fibers
Molecular Weight	Common options include 20–40, 100–150, and 500–750 kDa
Degree of Methacrylation / Substitution	Grade-dependent; examples include 10–30%, 35%, and 45–65%
Solubility	Generally water-soluble; depends on molecular weight and formulation
Crosslinking Method	Photocrosslinking with a compatible photoinitiator, or other validated crosslinking methods
Storage	Follow supplier instructions; refrigeration or frozen storage may be required
Quality Verification	COA, molecular-weight data, and NMR characterization, subject to availability

• Low Molecular Weight HAMA: For research formulations requiring lower-molecular-weight polymer.

• Medium Molecular Weight HAMA: Options around 100–150 kDa.

• High Molecular Weight HAMA: Options around 500–750 kDa.

• Low Substitution Grade: Lower methacrylate functionalization for selected hydrogel formulations.

• High Substitution Grade: Higher functionalization levels, subject to availability.

• Custom Research Grade: Molecular weight, substitution level, sterility, and endotoxin specifications evaluated by quotation.

1. What is methacrylated hyaluronic acid powder?

It is a modified hyaluronic acid polymer containing methacrylate functional groups that enable crosslinking to form hydrogels.

2. What is HAMA used for?

Common research uses include 3D bioprinting, tissue-engineering scaffolds, cell culture matrices, hydrogel development, and drug-delivery studies.

3. What molecular weights are available?

Commercial examples include 20–40 kDa, 100–150 kDa, and 500–750 kDa. Other molecular weights may be available through custom sourcing.

Sigma-Aldrich

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4. What degree of methacrylation should I select?

The appropriate level depends on the desired crosslinking behavior, hydrogel stiffness, degradation characteristics, and intended research protocol. Confirm the supplier's measurement method before comparing grades.

5. Is HAMA supplied as a powder?

Yes. Commercial products are commonly supplied as lyophilized powder, chunks, fibers, or other dry solid forms.

6. Can REG Metals provide a COA and SDS?

These documents can be requested during sourcing. Availability depends on the selected supplier and grade. For cell-based research, also confirm sterility, endotoxin levels, and any other required biological-quality specifications.